An extension to artifact-free projection overlaps

Purpose: In multipinhole single photon emission computed tomography, the overlapping of projections has been used to increase sensitivity. Avoiding artifacts in the reconstructed image associated with projection overlaps (multiplexing) is a critical issue. In our previous report, two types of artifactfree projection overlaps, i.e., projection overlaps that do not lead to artifacts in the reconstructed image, were formally defined and proved, and were validated via simulations. In this work, a new proposition is introduced to extend the previously defined type-II artifact-free projection overlaps so that a broader range of artifact-free overlaps is accommodated. One practical purpose of the new extension is to design a baffle window multipinhole system with artifact-free projection overlaps. Methods: First, the extended type-II artifact-free overlap was theoretically defined and proved. The new proposition accommodates the situation where the extended type-II artifact-free projection overlaps can be produced with incorrectly reconstructed portions in the reconstructed image. Next, to validate the theory, the extended-type-II artifact-free overlaps were employed in designing the multiplexing multipinhole spiral orbit imaging systems with a baffle window. Numerical validations were performed via simulations, where the corresponding 1-pinhole nonmultiplexing reconstruction results were used as the benchmark for artifact-free reconstructions. The mean square error (MSE) was the metric used for comparisons of noise-free reconstructed images. Noisy reconstructions were also performed as part of the validations.Results: Simulation results show that for noise-free reconstructions, the MSEs of the reconstructed images of the artifact-free multiplexing systems are very similar to those of the corresponding 1-pinhole systems. No artifacts were observed in the reconstructed images. Therefore, the testing results for artifact-free multiplexing systems designed using the extended type-II artifact-free overlaps numerically validated the developed theory. Conclusions: First, the extension itself is of theoretical importance because it broadens the selection range for optimizing multiplexing multipinhole designs. Second, the extension has an immediate application: using a baffle window to design a special spiral orbit multipinhole imaging system with projection overlaps in the orbit axial direction. Such an artifact-free baffle window design makes it possible for us to image any axial portion of interest of a long object with projection overlaps to increase sensitivity

Recovering Dense Tissue Multispectral Signal from in vivo RGB Images

Hyperspectral/multispectral imaging (HSI/MSI) contains rich information clinical applications, such as 1) narrow band imaging for vascular visualisation; 2) oxygen saturation for intraoperative perfusion monitoring and clinical decision making [1]; 3) tissue classification and identification of pathology [2]. The current systems which provide pixel-level HSI/MSI signal can be generally divided into two types: spatial scanning and spectral scanning. However, the trade-off between spatial/spectral resolution, the acquisition time, and the hardware complexity hampers implementation in real-world applications, especially intra-operatively. Acquiring high resolution images in real-time is important for HSI/MSI in intra-operative imaging, to alleviate the side effect caused by breathing, heartbeat, and other sources of motion. Therefore, we developed an algorithm to recover a pixel-level MSI stack using only the captured snapshot RGB images from a normal camera. We refer to this technique as "super-spectral-resolution". The proposed method enables recovery of pixel-level-dense MSI signals with 24 spectral bands at ~11 frames per second (FPS) on a GPU. Multispectral data captured from porcine bowel and sheep/rabbit uteri in vivo has been used for training, and the algorithm has been validated using unseen in vivo animal experiments.Comment: accepted by Hamlyn Symposium 201

Effect of architectural adjustments on pedestrian flow at bottleneck

In the last decades, a series of terrible accidents happened within pedestrian crowds, which makes crowd dynamic a significant issue to be investigated. Literature reviews show that pedestrian flow presents different features within different architectural layout. In this paper, pedestrian movement properties at bottleneck are studied by carrying out series of experiments under laboratory condition. The influence of door sizes and exit locations on pedestrian crowd flow is investigated. It was found that larger door width resulted in shorter evacuation time and faster flow rate. By comparing the fundamental diagram among crowd evacuation, the average velocity increases as the width increases under the same density condition. Interestingly, the influence of the boundary layer, as well as the effective width on pedestrian crowd dynamic, was clearly observed. Our results suggest that the combination of exit width and location resulted in a synergistic effect, but the exit widths gradually became the most important factor influencing the flow rate

Coastal Upwelling Off the China Coasts

Upwelling is an important oceanographic phenomenon that brings cooler and nutrient-rich water upward to the surface, facilitating the growth of phytoplankton and other primary producers, which results in high levels of primary productivity and hence fishery production. This chapter presents a review of recent studies on six major upwelling regions along the China coasts, with a focus on the eastern and southeastern coasts of mainland China, based on in situ measurements, satellite observations and numerical simulations. These upwelling regions result primarily from the summer monsoon winds, though other mechanisms, such as river discharge, baroclinicity, topography, tides, and the presence of mean current, may also be in play. In this review, their impacts on local biogeochemical processes are briefly summarized. Also discussed are their possible responses to the globally changing climate

Bayesian dense inverse searching algorithm for real-time stereo matching in minimally invasive surgery

This paper reports a CPU-level real-time stereo matching method for surgical images (10 Hz on 640 * 480 image with a single core of i5-9400). The proposed method is built on the fast ''dense inverse searching'' algorithm, which estimates the disparity of the stereo images. The overlapping image patches (arbitrary squared image segment) from the images at different scales are aligned based on the photometric consistency presumption. We propose a Bayesian framework to evaluate the probability of the optimized patch disparity at different scales. Moreover, we introduce a spatial Gaussian mixed probability distribution to address the pixel-wise probability within the patch. In-vivo and synthetic experiments show that our method can handle ambiguities resulted from the textureless surfaces and the photometric inconsistency caused by the Lambertian reflectance. Our Bayesian method correctly balances the probability of the patch for stereo images at different scales. Experiments indicate that the estimated depth has higher accuracy and fewer outliers than the baseline methods in the surgical scenario

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.

Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in vivo is unknown. We aim to observe the effects of mitochondria-specific, not cytoplasmic, Omi/HtrA2 on myocardial apoptosis and cardiac function. Transgenic mice overexpressing cardiac-specific mitochondrial Omi/HtrA2 were generated and they had increased myocardial apoptosis, decreased systolic and diastolic function, and decreased left ventricular remodeling. Transiently or stably overexpression of mitochondria Omi/HtrA2 in H9C2 cells enhance apoptosis as evidenced by elevated caspase-3, -9 activity and TUNEL staining, which was completely blocked by Ucf-101, a specific Omi/HtrA2 inhibitor. Mechanistic studies revealed mitochondrial Omi/HtrA2 overexpression degraded the mitochondrial anti-apoptotic protein HAX-1, an effect attenuated by Ucf-101. Additionally, transfected cells overexpressing mitochondrial Omi/HtrA2 were more sensitive to hypoxia and reoxygenation (H/R) induced apoptosis. Cyclosporine A (CsA), a mitochondrial permeability transition inhibitor, blocked translocation of Omi/HtrA2 from mitochondrial to cytoplasm, and protected transfected cells incompletely against H/R-induced caspase-3 activation. We report in vitro and in vivo overexpression of mitochondrial Omi/HtrA2 induces cardiac apoptosis and dysfunction. Thus, strategies to directly inhibit Omi/HtrA2 or its cytosolic translocation from mitochondria may protect against heart injury

Mechanical properties and energy absorption of ceramic particulate and resin-impregnation reinforced aluminium foams

The mechanical properties of aluminium foams can be improved by matrix reinforcement and resin-impregnation methods. In the present study, aluminium foams were reinforced by both ceramic particulate reinforcing of the aluminium matrix and resin-impregnating pores. The mechanical properties and the energy absorption of the reinforced aluminium foams were investigated by dynamic and quasi-static compression. Results indicated that the ceramic particle additions of CBN, SiC and B4C in aluminium foams increase the peak stress, elastic modulus and energy absorption of the aluminium foams, under both conditions of dynamic and quasi-static compression. Moreover, the aluminium foams with and without ceramic particle additions exhibited obvious strain rate sensitivity during dynamic compression. Furthermore, the resin-impregnation improves the mechanic properties and energy absorption of aluminium foams significantly. However, aluminium foams with resin-impregnation showed negligible strain rate sensitivity under dynamic compression. It is reported that both the ceramic particle addition and resin-impregnation can be effective techniques to improve the mechanical and the energy absorption properties of aluminium foams.<br /

A peculiar lens-shaped structure observed in the South China Sea

Lens-shaped structures within thermocline potentially play a significant role in subsurface transport of mass, heat, and salt in the global ocean. Whilst such structures have been documented in many oceanic regions, none has been observed in the China Seas. This study reports on observations of a lens-shaped structure within thermocline in the southwestern South China Sea in September 2007. This structure had a maximum thickness of approximately 60 m and a horizontal extent exceeding 220 km. This lens was peculiar in that its size is larger than most similar structures documented in the literature. The lens core was characterized by well-mixed water with higher temperature (~28.8 °C), lower salinity (~33.3) and lower potential vorticity (PV) compared to the surrounding waters. Based on an ocean reanalysis, possible generation mechanism of the lens is explored by examining the evolution of surface and subsurface thermohaline properties, and an analysis of vertical PV flux. The lens was likely generated by a mixture of the local mixed-layer water and the water from the coastal jet separation site